fit_batch_reference

fit_batch_reference(
    data,
    *,
    batch_col,
    covariates=(),
    protect=('condition', 'group'),
    min_batch=MIN_BATCH,
)

Fit the frozen global parameters on a reference cohort.

Parameters

Name	Type	Description	Default
covariates	Sequence[str]	Columns of obs whose effect should be preserved rather than removed – typically age and sex. Numeric columns enter as themselves; categorical ones as dummies.	()
protect	Sequence[str]	Columns checked for being nested inside batch. See :func:_check_confounding; pass () to skip.	('condition', 'group')