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Functional marker blocks, transcribed from the document's four scoping rules

Source: R/populations.R
default_functional_blocks.Rd

Scope is expressed as a RULE, not a hardcoded population list, so that adding a population to the config automatically scores it under the right blocks: exclude = populations to omit (everything else is included) require = only populations whose definition requires this marker "above"

Usage

default_functional_blocks()

Details

Document rules, verbatim in intent: exhaustion (LAG-3/TIM-3/PD-1/CTLA-4) – "in each cell subset except for monocytes CD14, CD16 and CD14 int CD16 int" homing (CCR5/CCR9/CXCR3) – "in CD3 pos subsets" activation (CD69/HLA-DR/CD25/CD57/CD38) – "in CD3 pos subsets" monocyte (HLA-DR/BTN2A2/BTN3A1/2/3) – "in CD14 pos, CD16 pos, and CD14 int CD16 int subsets"